Chemical & analytical development


Macfarlan Smith offers a complete process and analytical development service to the pharmaceutical industry. A comprehensive package is available from early route synthesis through to bulk production and process validation

Chemical Development

  • Literature review and assessment of synthetic opportunities
  • Development or new and existing synthetic routes for both known and new chemical entities (includes potents and natural product extractions)
  • Process optimisation and scale up to kilo scale production

Analytical Development

  • Analytical method development
  • Method validation and technical transfer
  • Impurity profiling/ identification/ characterisation
  • Stability testing to ICH Guidelines

HPLC machine

Modern Analytical capabilities include:

  • UV, FTTR, GLC, HPLC, NMR, particle size testing, full microbiological testing, XRPD, LC-MS, MC-MS, physio-chemical reaction hazard testing

Macfarlan Smith also has access to a number of additional resources through the Johnson Matthey group. These include:

  • Extensive information services such as patents and intellectual property departments
  • World Class technology research centre
  • Chiral technologies
  • Process catalysts
  • Catalytic screening and optimisation